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 SARS-CoV-2 COVID-19


In view of the rapidly developing  COVID-19 global pandemic, our focus has been redirected to this disease's pathology, potential therapeutic targets and treatment approaches. Our  publications  in this field  are shown below:

More Update to Follow

Possible use of the mucolytic drug, bromhexine hydrochloride, as a prophylactic agent against SARS-CoV-2 infection based on its action on the Transmembrane Serine Protease 2. Pharmacological Research (IF 5.574.

4.            Available online: 30 April 2020

Should we try the anti-inflammatory natural product, celastrol, for COVID-19? Published Online: 29 April 2020.

 

SARS-CoV-2 infection, COVID-19 and other coronavirus diseases.. Visit our new Special Issue for article contribution.

COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help.  If they have efficacy against COVID-19, this could be what we need to do improve their safety and efficacy ..

Watch Our Video Presentation

Lessons learned from SARS-CoV and MERS-CoV: FDA-approved Abelson tyrosine-protein kinase 2 inhibitors may help us to combat SARS-CoV-2. Archives of Medical Science. Published on 14 April 2020.

4.             

Repurposing Therapeutic Agents and Herbal Medicines to Defeat Viral Nemesis  - Published on 30 March 2020 - Drug Development Research

Other  Publications on Our Antiviral Activity Studies

See our  article on antiviral activity of Tansy: Álvarez, Á.L,  HABTEMARIAM, S,  Juan-Badaturuge,  M, Jackson, C, Parra, F. (2011).  In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: An approach to their mechanisms of action.  Phytotherapy Research. 25(2), 296-301.  Abstract
...See an overview of our Research on Tansy...

...See media coverage of our findings...

Álvarez, Á.L., HABTEMARIAM, S., Dalton, K.P., Nicieza, I., Parra, F. (2015. A spiroketal-enol ether derivative from Tanacetum vulgare selectively inhibits HSV-1 and HSV-2 glycoprotein accumulation in Vero cells. Antiviral Research 119, 8-18. Abstract

.... and  visit our publications' page for more references.

Bioassays on Antimicrobial Effects of Natural Products

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The Site Owner

Dr Habtemariam BSc, MSc, PhD........FRSM, FRSC. .... With a Principal Lecturer post at Greenwich, Dr Habtemariam has been a  leader of courses and researches on bioassay & natural products-based drug development. ....More

 

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In addition to our fully equipped tissue culture facilities, we have  access to various state-of-the-art equipment including ICP-MS, LC-MS, MALDI-TOF-MS, FABS-MS, FTIR, Laser-Raman,  scanning  and transmission  electron microscopes, flow cytometer, NMR (300, 400 and 500MHz),  automated DNA sequencers, various HPLC systems,  capillary electrophersis ................

 

 

 

 

 

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